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November 30, 2025iMetaMedOpen Access

Immunometabolic Features and Key Biomarkers in Lung Cancer Complicated by Pulmonary Tuberculosis: Insights From Transcriptome and Clinical Cohort Analysis

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Authors

LYLing YangSLShanshan LiGBGuangliang Bai

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Overview

Transcriptional analysis reveals key biomarkers in lung cancer complicated by tuberculosis, suggesting treatment challenges.

Key Points

  • Increased CD4/CD8 ratio and other immunometabolic features suggest lung cancer may complicate tuberculosis.
  • Transcriptome analysis identified significant changes with 144 upregulated genes in lung cancer with tuberculosis.
  • Study involved cohort analysis of 138 subjects, including lung cancer and tuberculosis patients, using advanced bioinformatics techniques.
  • A validated four-gene model discriminates patients with lung cancer complicated by tuberculosis for better diagnosis.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/692b94601d383f2b2a3792dbhttps://doi.org/10.1002/imm3.70015
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