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September 10, 2025Journal of Pure and Applied MicrobiologyOpen Access

Decoding Immune and Metabolic Dysregulation in COPD and Tuberculosis: Insights from Systems Biology and Transcriptomics

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Authors

AKAbida KhanHAHayat Ali AlzahraniRERanya Mohammed Elmagzoub

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Overview

This research identifies key genes involved in immune dysregulation in COPD and tuberculosis, suggesting potential therapeutic targets.

Key Points

  • Key genes such as RELA and PLK3 are consistently upregulated, contributing to chronic inflammation.
  • Pathway enrichment analysis shows significant involvement of nf-κb signaling and cytokine-mediated pathways.
  • PPI analysis highlights regulatory hubs like STAT1 and GBP5 as potential therapeutic targets.
  • Single-cell RNA sequencing locates dysregulated genes to alveolar macrophages, underscoring their role in disease.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/68c2416eb210217d6479f4edhttps://doi.org/10.22207/jpam.19.3.12
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