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October 9, 2025Frontiers in MedicineOpen Access

A novel circulating miRNA panel for early differential diagnosis of pulmonary tuberculosis from lung cancer with similar radiographic presentations

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Authors

XLXiao LiuWWWentao WangYFYurong Fu

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Overview

Observational analysis identifies a specific miRNA panel, achieving AUC of 0.911 in distinguishing pulmonary tuberculosis from lung cancer.

Key Points

  • A diagnostic panel of specific miRNAs demonstrated a robust AUC of 0.911 for distinguishing pulmonary tuberculosis from lung cancer.
  • In the discovery phase, expression profiles of 284 individuals were analyzed, revealing significant upregulation of certain miRNAs in PTB patients.
  • The validation cohort included 308 plasma samples; the sensitivity of the miRNA panel reached 0.879 in differentiating PTB from LC.
  • These findings suggest that miRNA-based diagnostics could serve as a non-invasive tool, filling a critical gap in pulmonary disease management.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68e79cf2ed88661f66c2e0c9https://doi.org/10.3389/fmed.2025.1660291
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