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November 28, 2025Clinical and Experimental MedicineOpen Access

FGD5-AS1 and Th1/Th2 imbalance in the progression of diabetic nephropathy: evidence from bioinformatic and experimental validation

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Authors

PAParisa AjorlouSHSeyed Amirhossein HosseiniAGAmin Ghanbarnejad

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Overview

Analysis reveals cytokine imbalances in type 2 diabetes and diabetic nephropathy, suggesting new therapeutic targets for treatment.

Key Points

  • Diabetic nephropathy is linked to an imbalance in Th1/Th2 immune cells, with increased Th1 activity in microalbuminuria and ESRD.
  • Significant findings showed upregulation of TBX21 and IFN-γ in patients with diabetic nephropathy.
  • Real-time PCR analysis was used to measure expression levels of key transcription factors and cytokines involved in immune response.
  • These results suggest that therapeutic targeting of inflammatory pathways may enhance precision medicine approaches in diabetic nephropathy.

Cite This Study

Ajorlou et al. (2025) studied this question.

synapsesocial.com/papers/6928f11ba65b730b9ea7a166https://doi.org/10.1007/s10238-025-01946-y
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