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November 30, 2025Frontiers in GeneticsOpen Access

Identification and experimental validation of demethylation-related genes in diabetic nephropathy

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Authors

HMHui MiaoYZYunke ZhuJZJiaqi Zheng

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Overview

Bioinformatics methods reveal CXCL2 as a key biomarker for diabetic nephropathy, suggesting potential treatment pathways.

Key Points

  • CXCL2 was identified as a diagnostic biomarker for diabetic nephropathy, indicating its elevated expression levels compared to the normal group.
  • The study conducted a comprehensive analysis using bioinformatics methods to identify demethylation-related genes in diabetic nephropathy and validate them as biomarkers.
  • Receiver operating characteristic curves confirmed the predictive accuracy of biomarkers, linking them with key molecular interactions and signaling pathways.
  • Subcellular localization and immune infiltration analyses suggested a complex relationship involving tumor suppressor genes and various immune cells in diabetic nephropathy.

Cite This Study

Miao et al. (2025) studied this question.

synapsesocial.com/papers/692b9d831d383f2b2a3796bfhttps://doi.org/10.3389/fgene.2025.1675592
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