Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
October 9, 2025Journal of Diabetes ResearchOpen Access

Gene Expression in Urinary Sediment Cells as an Indicator of the Contribution of Plasma Lipids to Diabetic Kidney Disease

View Full Paper
Ask AI
Bookmark
Share

Authors

TZThainá Tavolaro ZocchioASAritânia Sousa SantosACAna Mercedes Cavaleiro

Discussion

Loading...

Member takes

Overview

Observational analysis reveals correlations between mRNA expression in urinary sediment cells and lipid profiles in type 1 diabetes, indicating metabolic involvement in diabetic kidney disease.

Key Points

  • Higher CD36 expression in urinary sediment cells relates to renal function decline in type 1 diabetes patients.
  • Notable correlations exist between CD36, IL1B, TGFB1, and urinary albumin excretion levels.
  • Plasma free fatty acid levels correlate positively with mRNA expression of CD36 and IL1B, linking lipids to kidney health.
  • The expression of lipid-related genes was modulated by statin and angiotensin II receptor blocker use, highlighting treatment impact.

Cite This Study

Zocchio et al. (2025) studied this question.

synapsesocial.com/papers/68e79cf2ed88661f66c2e2b8https://doi.org/10.1155/jdr/2349928
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FGD5-AS1 and Th1/Th2 imbalance in the progression of diabetic nephropathy: evidence from bioinformatic and experimental validation2025
  2. 2Impact of UTI in Both T2DM with and without Nephropathy on Renal Function Tests and Novel Biomarkers (Liver Fatty Acid Binding Protein (LFABP) and Secretory Leukocyte Protease Inhibitor (SLPI))2025
  3. 3Identification of key lipid metabolism-related genes in kidney fibrosis: implications for chronic kidney disease management2025
  4. 4Glycated CD59 as a Novel Biomarker of Diabetic Nephropathy: Links to Microalbuminuria, Tubular Injury, and Complement Activation2025
  5. 5Decreased Serum Adipose Triglyceride Lipase Level Is Associated With Renal Function Impairment in Patients With Type 2 Diabetes2025