What type of study is this?

This is a In Vitro Study study.

November 28, 2025Molecular CancerOpen Access

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization

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Authors

CMChenglong Ma RLRuocen Liao XCXingyu Chen

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Implication

In vitro and clinical studies reveal that RHOA lactylation enhances tumor progression in breast cancer, suggesting metabolic reprogramming may drive oncogenic activity.

Key Points

Lactylation of RHOA enhances protein stability and promotes tumor cell invasion and metastasis.
Key findings include increased protein stability through ubiquitination regulation and metabolic reprogramming.
Assessment using lactylation assays and GTPase activity measurements provides insights into RHOA functions.
Addressing lactylation and canonical tumor pathways may represent effective therapeutic strategies.

Cite This Study

Ma et al. (2025) studied this question.

synapsesocial.com/papers/6928f113a65b730b9ea79e6f https://doi.org/10.1186/s12943-025-02511-7

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Implication

In vitro and clinical studies reveal that RHOA lactylation enhances tumor progression in breast cancer, suggesting metabolic reprogramming may drive oncogenic activity.

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization

Discussion

Member takes

Implication

Key Points

Cite This Study

RHOA lactylation at oncogenic hotspots promotes oncogenic activity and protein stabilization

Discussion

Member takes

Implication

Key Points

Cite This Study

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