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September 10, 2025Oncology LettersOpen Access

Effects of lactylation on the hallmarks of cancer (Review)

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Authors

YFYujie FanAnhui Medical UniversityZCZ. ChenJLJiaxin LiShanghai Jiao Tong University

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Implication

Review highlights lactylation's role in cancer hallmarks and metabolic reprogramming, suggesting new therapies.

Key Points

  • Lactylation drives the acquisition of hallmark features of cancer, including sustained proliferative signaling.
  • Systematic review details lactylation's regulation of histone and non-histone proteins in cancer progression.
  • Targeting lactylation pathways may enhance treatment efficacy against resistant cancer phenotypes.
  • Immunosuppressive tumor microenvironment shaped by lactylation complicates therapy, indicating urgent research needs.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a4a8ahttps://doi.org/10.3892/ol.2025.15238
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