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September 12, 2025Cancer Management and ResearchOpen Access

Bioinformatics Analysis and Experimental Validation of Lactylation Related Genes in Lung Adenocarcinoma

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Authors

LGLi GaoYZY-C. ZhangFWFengrui Wu

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Overview

Bioinformatics analysis reveals lactylation as a potential prognostic marker in lung adenocarcinoma, highlighting therapeutic targets.

Key Points

  • Lactylation levels are elevated in lung adenocarcinoma tissues, indicating a potential prognostic role.
  • Differential expression identified 17 lactylation-related genes, with five key risk genes associated with prognosis.
  • Analysis included methods like immunohistochemistry and single-cell RNA sequencing to validate findings.
  • Findings suggest lactylation-related genes could serve as biomarkers and therapeutic targets in lung adenocarcinoma.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68d41ed9713b0b5dfea67c4ehttps://doi.org/10.2147/cmar.s533289
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lactylation-Associated Prognostic Model and Role of ANLN in Pancreatic Ductal Adenocarcinoma2025
  2. 2Integrative analysis of lactylation related genes in prostate cancer: unveiling heterogeneity through single-cell RNA-seq, bulk RNA-seq and machine learning2025
  3. 3Development and Validation of Palmitoylation-Related Genes in the Prognostic and Immunologic Characterization of Lung Adenocarcinoma2025 · 1 citations
  4. 4Lactylation in cancer biology: Unlocking new avenues for research and therapy2025
  5. 5Lactylation in Cancer: Advances, Challenges, and Future Perspectives.2025