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August 14, 2025Journal of Translational MedicineOpen Access

Nonhistone lactylation: A hub for tumour metabolic reprogramming and epigenetic regulation

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Authors

DZDawei ZhangCLCong LiangCWChengwei Wu

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Overview

Review of lactylation in tumour metabolism and epigenetics highlights potential therapeutic targets.

Key Points

  • Lactylation in nonhistones drives tumour growth and immune evasion by modifying gene expression, signalling, and repair mechanisms.
  • The review emphasizes the role of lactate in the tumour microenvironment, increasing chemotherapy and immunotherapy resistance via various pathways.
  • Comprehensive analysis of therapeutic strategies targeting enzymes like LDH and AARS1 outlines new avenues for cancer treatment.
  • Future studies must focus on lactylation dynamics to develop targeted interventions for effective tumour therapies.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68a34f4c234c60ad5c20b735https://doi.org/10.1186/s12967-025-06813-8
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