Lactylation-driven molecular taxonomy of melanoma: linking epigenetic modifications to immune evasion and clinical outcomes

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High-risk melanoma tumors exhibit significant immune suppression and altered immune cell profiles.
A six-gene lactylation signature successfully stratifies patients into different survival risk groups.
Pathway analyses indicate key signaling mechanisms involved in the aggressive traits of melanoma.
Functional validation establishes lactylation's role in enhancing melanoma cell growth and migration.

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Single-cell RNA sequencing reveals lactylation impacts immune evasion and clinical outcomes in melanoma.

Wang et al. (2025) studied this question.

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