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November 25, 2025The Journal of Immunology

Metabolic adaptions of regulatory T cells in non-lymphoid tissues 2558

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Authors

PDPamela P. Diaz-SaldanaMKMinjae KimCECody Elkins

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Overview

Research reveals glycolytic dependency of regulatory T cells in non-lymphoid tissues, implying new therapeutic targets for autoimmune diseases.

Key Points

  • This research investigates the metabolic adaptations of regulatory T cells in non-lymphoid tissues.
  • Utilized Single Cell ENergetIc metabolism by profiling Translation inHibition (SCENITH) assay
  • Assessed metabolic dependencies and capacities of non-lymphoid tissue regulatory T cells
  • Examined the effects of genetic ablation of key glycolytic regulators on Treg accumulation in non-lymphoid tissues.
  • NLT Tregs exhibit high glycolytic capacity and dependency compared to SLO Tregs.
  • Genetic ablation of glycolytic regulators reduced Treg accumulation in certain NLTs.
  • Findings suggest glycolysis plays a crucial role in the tissue-specific adaptation of NLT Tregs.

Cite This Study

Diaz-Saldana et al. (2025) studied this question.

synapsesocial.com/papers/692502dc87af00ed34ac2a6dhttps://doi.org/10.1093/jimmun/vkaf283.464
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