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October 9, 2025European Journal of Immunology

Purin Metabolism Is Crucial for Regulatory T Cell Stability and Function

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Authors

YLYoung Shin LeeMSMarina W. ShirkeyVSVikas Saxena

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Overview

Review finds that purine metabolism influences Treg stability and function, suggesting implications for autoimmunity and transplantation.

Key Points

  • Purine metabolism is critical for maintaining the function and stability of regulatory T cells, which are essential for immune regulation.
  • Disruptions in purine signaling may lead to negative states like exTregs, impairing immune response in conditions like autoimmunity and organ transplantation.
  • The review highlights the role of external ATP and adenosine in regulating Tregs, indicating a complex relationship between metabolism and immune function.
  • Understanding purinergic signaling in Tregs opens avenues for therapeutics in immune-related diseases and highlights current knowledge gaps.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/68e70db790569dd607ee6667https://doi.org/10.1002/eji.70070
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic adaptions of regulatory T cells in non-lymphoid tissues 25582025
  2. 2Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism2025
  3. 3Intronic miR-342 is a key regulator of cellular glycolysis in Foxp3+ regulatory CD4 T cells2025
  4. 4Purine nucleobases enhance CD8+ T cell effector function2025
  5. 5Metabolism-driven posttranslational modifications and immune regulation: Emerging targets for immunotherapy.2025 · 24 citations