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August 14, 2025The Journal of Immunology

Intronic miR-342 is a key regulator of cellular glycolysis in Foxp3+ regulatory CD4 T cells

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Authors

RYRongzhen YuSKSohee KimSLSilei Li

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Overview

Findings reveal that miR-342 manages glycolysis in Treg cells, suggesting its role in autoimmunity and inflammation.

Key Points

  • Elevated glycolysis was observed in Treg cells deficient in miR-342, leading to dysfunction and inflammatory responses.
  • Treg cells with miR-342 overexpression effectively mitigated ongoing autoimmune inflammation in a model, demonstrating its therapeutic potential.
  • Observational analysis using mouse models highlighted that miR-342 deficiency disrupts metabolic profiles specifically in Treg cells.
  • miR-342's regulatory role in Treg cells emphasizes the importance of metabolic processes in immune regulation and tolerance.

Cite This Study

Yu et al. (2025) studied this question.

synapsesocial.com/papers/68c23595b210217d6477196bhttps://doi.org/10.1093/jimmun/vkaf181
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