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October 15, 2025Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 )

Protective Effects of Irigenin against Cyclophosphamide-induced Nephrotoxicity in Male Rats: Comparative Study with Vitamin E

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Authors

TATarfa AbedNANada N. Al-Shawi

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Overview

Experimental study shows irigenin improves kidney function in rats exposed to cyclophosphamide, indicating potential as an antioxidant therapy.

Key Points

  • Irigenin significantly reduced biomarkers of kidney damage, enhancing renal function in treated rats.
  • Cyclophosphamide treatment increased malondialdehyde, creatinine, and urea levels, while irigenin pretreatment reversed these effects.
  • Histological examination confirmed that irigenin offered nephroprotective effects against toxic damage due to cyclophosphamide.
  • Assessment involved analyzing various biochemical markers in kidney tissue from male albino rats over 29 days.

Cite This Study

Abed et al. (2025) studied this question.

synapsesocial.com/papers/68eff7392ae617e5891a91eehttps://doi.org/10.54133/ajms.v9i2.2316
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ameliorative effects of Spirulina platensis niosome and Echinacea purpura on cyclophosphamide-induced splenic, cardiac and neurotoxicity via modulating NF-κB pathway and oxidative stress2026
  2. 2Nephroprotective Effect of Naringenin and Bromelain Against Cisplatin-Induced Renal Toxicity in Rats2024
  3. 3Nephroprotective Role of Ichnocarpus frutescens Leaf Extract Against Cisplatin-Induced Renal Injury: Evidence from Rat and HK-2 Cell Models via Nrf2–HO-1–GPX4 Axis Modulation2025
  4. 4Riociguat Alleviates Cisplatin-Caused Kidney Injury by Suppressing Oxidative Stress and Inflammation2025
  5. 5Arbutin as a potential nephroprotective agent: Dose-related effects in renal ischemia-reperfusion injury2025