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September 10, 2025International Journal of experimental research and reviewOpen Access

Nephroprotective Role of Ichnocarpus frutescens Leaf Extract Against Cisplatin-Induced Renal Injury: Evidence from Rat and HK-2 Cell Models via Nrf2–HO-1–GPX4 Axis Modulation

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Authors

ACAashish ChoudharyKPKamala Kanta ParhiSJShridhar Jayagopalan

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Overview

Experimental analysis shows that ichnocarpus frutescens reduces oxidative stress in renal models, indicating its nephroprotective potential against cisplatin toxicity.

Key Points

  • ALIF significantly reduced serum creatinine, BUN, uric acid, and electrolyte disturbances in rats, revealing its nephroprotective effect.
  • Renal protective functions were linked to modulation of the nrf2–ho-1–gpx4 axis, providing a targeted approach to mitigate nephrotoxicity.
  • The study established that ALIF restored cell viability and reduced oxidative stress in HK-2 cells, emphasizing its cellular protective role.
  • Histopathological assessments confirmed that ALIF preserved renal architecture, marking its potential as a valuable adjunct in cisplatin chemotherapy.

Cite This Study

Choudhary et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d64782610https://doi.org/10.52756/ijerr.2025.v48.002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 14-Methoxylonchocarpin protects against cisplatin induced acute kidney injury via regulating ferroptosis2025
  2. 2Nephroprotective Effect of Naringenin and Bromelain Against Cisplatin-Induced Renal Toxicity in Rats2024
  3. 3Taxifolin Attenuates Cisplatin‐Induced Acute Kidney Injury by Promoting Fatty Acid Oxidation2025
  4. 4Cilostazol Ameliorates Cisplatin-induced Nephrotoxicity via Modulation of PI3K/AKT/mTOR Signaling Pathway and Autophagy in Rats.2025 · 2 citations
  5. 5Quinic acid attenuates cisplatin-induced acute kidney injury by modulating inflammatory cytokines, oxidative stress, apoptosis, and the Nrf2/HO-1/NQO1 pathway in rats2026