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September 16, 2025Trends in Sciences

Nephroprotective Effect of Naringenin and Bromelain Against Cisplatin-Induced Renal Toxicity in Rats

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Authors

KPKajal PansareYAYogesh AhireVBVinod Bairagi

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Overview

Observational analysis shows Naringenin and Bromelain significantly reduce renal toxicity in rats, indicating potential adjunct therapies for chemotherapy.

Key Points

  • Combination of high-dose naringenin and bromelain significantly restores renal function after cisplatin exposure.
  • Significant improvements were observed in serum urea, creatinine, and pro-inflammatory cytokines with treatment.
  • Histopathological assessment revealed marked preservation of renal architecture following naringenin and bromelain treatment.
  • The study demonstrates that naringenin and bromelain may provide protective benefits against cisplatin-induced nephropathy.

Cite This Study

Pansare et al. (2024) studied this question.

synapsesocial.com/papers/68d441a6713b0b5dfea80a48https://doi.org/10.48048/tis.2025.10681
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