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December 4, 2025Nutrition & MetabolismOpen Access

High-fructose diet induces depressive-like behaviors and short-term memory deficits through hippocampal neurogenesis impairment via neural stem cell dysfunction

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Authors

QWQiaona WangYWYong‐Fa WangYHYuefeng Hu

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Overview

Observational analysis shows high-fructose diet causes neurogenesis impairment in mice, highlighting risks for neuropsychiatric disorders.

Key Points

  • Depressive-like behaviors were observed in mice with a high-fructose diet, alongside memory deficits.
  • Mice exhibited impaired short-term memory in the novel object recognition test, indicating cognitive decline.
  • Behavioral assessments included tail suspension and elevated plus maze tests to evaluate anxiety-like behaviors.
  • Findings suggest a link between high-fructose diet, metabolic dysregulation, and neuropsychiatric risks.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6930e8d7ea1aef094cca3ae9https://doi.org/10.1186/s12986-025-01043-7
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