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October 15, 2025Iranian Journal of MicrobiologyOpen Access

Assessing the beneficial effect of Lactobacillus plantarum MS1 and Lactobacillus delbrueckii YN1 on colitis in a rat model

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Authors

MVManizheh Hajizadeh VarzeghanGZGholamreza ZarriniFHFarzam Sheikhzadeh Hesari

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Overview

This research demonstrates that lactobacillus plantarum and lactobacillus delbrueckii reduce inflammation in colitis, suggesting a potential treatment for IBD.

Key Points

  • Probiotic treatment in rats significantly reduced inflammation and improved mucosal health.
  • Both probiotic strains improved key inflammatory markers, indicating potential for IBD therapy.
  • Histopathological analyses revealed decreased crypt abscesses and inflammatory cell infiltration.
  • Mesalazine showed limited effects in comparison to the probiotics in improving colitis symptoms.

Cite This Study

Varzeghan et al. (2025) studied this question.

synapsesocial.com/papers/68ef858cc6a308ba06355641https://doi.org/10.18502/ijm.v17i5.19889
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