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November 25, 2025The Journal of ImmunologyOpen Access

Treatment of Lactobacillus paracasei KBL382 modulates intestinal inflammation and colonic integrity, with therapeutic benefits in IBD mouse models 9027

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Authors

GKGwang Pyo Ko

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Overview

Pre-clinical evaluation shows Lactobacillus paracasei KBL382 reduces pro-inflammatory cytokines in IBD, indicating therapeutic potential.

Key Points

  • Assess the therapeutic impact of Lactobacillus paracasei KBL382 on intestinal inflammation and integrity in IBD models.
  • Evaluated effects of KBL382 in pre-clinical models of intestinal disease.
  • Measured pro-inflammatory and anti-inflammatory cytokines in human PBMCs.
  • Conducted intestinal permeability assays and molecular marker analysis.
  • Analyzed changes in gut microbiome diversity.
  • KBL382 reduced pro-inflammatory cytokines and enhanced anti-inflammatory responses.
  • Significantly improved clinical symptoms in DSS- and TNBS-induced IBD mouse models.
  • Positive changes observed in gut microbiome alpha and beta diversities.

Cite This Study

Gwang Pyo Ko (2025) studied this question.

synapsesocial.com/papers/692502d187af00ed34ac27b9https://doi.org/10.1093/jimmun/vkaf283.2490
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