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September 11, 2025Open Access

Enteric ChAT-expressing neurons as new target for Lactobacillus plantarum ameliorates inflammatory bowel diseases

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Authors

BXBing XiaYSYuwei SunJWJialin Wang

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Overview

Observational analysis shows Lactobacillus plantarum improves colitis in mice, indicating a new neuro-immune pathway.

Key Points

  • Lactobacillus plantarum A736 significantly ameliorated DSS-induced colitis in mice, demonstrating its therapeutic potential.
  • This strain enhanced the abundance of choline acetyltransferase-expressing neurons and elevated acetylcholine levels.
  • Multi-omics analysis unveiled the metabolite indole-3-lactic acid as key in activating ChAT+ neurons, supporting gut immunity.
  • These findings highlight the potential of targeting the ILA-ChAT+ neuron axis for effective IBD treatment.

Cite This Study

Xia et al. (2025) studied this question.

synapsesocial.com/papers/68d41717713b0b5dfea62cedhttps://doi.org/10.1101/2025.09.09.673902
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