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September 10, 2025Diseases of the Esophagus

A Genomic Analysis of Squamous Cell Carcinoma of the Oesophagus Following Neoadjuvant Chemotherapy

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Authors

NKNaveen KumarRPRaja PramanikVVVidya Valore

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Overview

This study identifies genomic alterations in esophageal cancer patients post-chemotherapy, suggesting potential implications for treatment. Key mutations correlate with poor responses to therapy.

Key Points

  • Genomic and transcriptomic alterations were identified in esophageal squamous cell carcinoma, impacting treatment responses.
  • Key findings show that 92.5% of pre-operative samples had mutations, with significant pathways altered in cell cycle and protein metabolism.
  • The research involved 130 patients undergoing neoadjuvant chemotherapy, analyzing pre- and post-operative tissue samples.
  • Results suggest that molecular profiling can guide personalized treatment strategies, enhancing patient selection and outcomes.

Cite This Study

Kumar et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478b7c6https://doi.org/10.1093/dote/doaf061.218
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1475. COMPREHENSIVE GENOMIC AND TRANSCRIPTOMIC ANALYSES REVEAL PROGNOSTIC STRATIFICATION FOR ESOPHAGEAL SQUAMOUS CELL CARCINOMA2025
  2. 2Integrative analyses of single‐cell and bulk RNA sequencing reveal tumour microenvironment features associated with neoadjuvant immunochemotherapy response in oesophageal squamous cell carcinoma2025
  3. 3Molecular Subtypes of Esophageal Squamous Cell Carcinoma Driven by N- Glycosylation and Construction of a Machine Learning-Based Prognostic Model2025
  4. 4Gene‐specific ctDNA dynamics predict tumour burden and survival outcomes in ESCC: A prospective cohort study2025 · 4 citations
  5. 5142. PREDICTIVE ROLE OF CTDNA IN ESOPHAGEAL SQUAMOUS CELL CARCINOMA RECEIVING NEOADJUVANT IMMUNOTHERAPY AND CHEMOTHERAPY: A PROSPECTIVE COHORT STUDY2025