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October 2, 2025Frontiers in Aging NeuroscienceOpen Access

Western diet-induced visceral adipose tissue inflammation promotes Alzheimer’s disease pathology via microglial activation in a mouse model

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Authors

JLJi Sun LimSKS. KwakMYMi-Hee Yu

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Overview

Observational analysis shows microglial activation increases neuroinflammation in Alzheimer's disease, implying targeting inflammation may reduce progression.

Key Points

  • Western diet feeding significantly increased neuroinflammatory markers and Alzheimer's-related proteins in mice.
  • Increased levels of pro-inflammatory cytokines were identified through RNA sequencing and plasma profiling.
  • Microglial activation via IL-6/STAT3 signaling was confirmed, leading to hippocampal neuronal cell death.
  • Findings highlight a systemic-neuroinflammatory axis that connects adipose tissue inflammation to Alzheimer's disease pathology.

Cite This Study

Lim et al. (2025) studied this question.

synapsesocial.com/papers/68de68f683cbc991d0a21ea2https://doi.org/10.3389/fnagi.2025.1644988
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