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September 5, 2025Frontiers in NeuroscienceOpen Access

Systemic lipid and glucose modulation differentially affects cognitive function and neuroinflammation in a mouse model of Alzheimer’s disease

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Authors

DKDemos KynigopoulosEFEleni FellaLSLucy Shahabian

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Overview

Observational analysis reveals altered neuroinflammation and cognitive function in a mouse model of Alzheimer's disease, suggesting metabolic interventions may offer therapeutic benefits.

Key Points

  • Alirocumab treatment improved spatial working memory and restored hippocampal function in a mouse model of Alzheimer's disease.
  • Gliclazide reduced neuroinflammation and partially preserved neuronal markers, indicating effects on glial health.
  • Both treatments decreased amyloid burden and influenced adipokine levels, highlighting the metabolic-cognitive link.
  • Lipidomic profiling showed distinct changes, suggesting therapeutic pathways between systemic metabolism and central nervous system function.

Cite This Study

Kynigopoulos et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477ab80https://doi.org/10.3389/fnins.2025.1636624
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting Metabolic Dysregulation in Alzheimer’s Disease: A Potential Therapeutic Strategy2025 · 8 citations
  2. 2Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health2025
  3. 3Adipokines at the Metabolic–Brain Interface: Therapeutic Modulation by Antidiabetic Agents and Natural Compounds in Alzheimer’s Disease2025 · 12 citations
  4. 4Lipid and Lipoprotein Metabolism in Microglia: Alzheimer’s Disease Mechanisms and Interventions2025
  5. 5Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer knock-in mouse phenotypes2025