Photoredox-Catalyzed Hydrofluoromethylthiolation of Unactivated Alkenes to Access Alkyl Di- and Trifluoromethyl Sulfides

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This method achieves up to 93% yield for the synthesis of alkyl di- and trifluoromethyl sulfides.
With 47 examples tested, the reaction demonstrates excellent chemo- and regioselectivity under mild conditions.
The approach uses organic photocatalysis to eliminate the need for metal and oxidants, enhancing environmental compatibility.
Preliminary studies suggest a radical pathway is involved, pointing to potential applications in drug functionalization.

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Visible-light photocatalysis achieves high yields in aliphatic di- and trifluoromethyl sulfides, indicating a more benign method.

Feng et al. (2025) studied this question.

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