August 11, 2025

Organophotoredox-catalyzed Trifluoromethylative Cyclization of Alkenoic Thioesters

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Visible-light-induced trifluoromethylative cyclization produces sulfur heterocycles, suggesting new avenues in photoredox catalysis.

Trifluoromethylative cyclization of alkenoic thioesters produces CF3-substituted sulfur heterocycles.
The method achieves high diastereoselectivity with a broad range of substrates, enhancing synthetic versatility.
Mechanistic studies highlight an oxidative quenching pathway, driven by interactions between photocatalyst and reagent.
This approach expands synthetic applications for alkenyl thioesters in the field of photoredox catalysis.

Sasaki et al. (2025) studied this question.

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