Photocatalytic Vicinal Trifluoromethylation and Disulfuration of Alkenes Using Langlois' Reagent and Tetrasulfides

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The study reveals a novel method for creating trifluoromethyl-containing disulfides using photocatalysis.
Experimental investigations support the proposed radical-reaction pathways with varied techniques, including cyclic voltammetry.
The approach leverages Langlois' reagent and symmetrical tetrasulfide to enable late-stage modifications of drug derivatives.
The findings may enhance the development of scalable synthetic processes in pharmaceutical chemistry.

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This method demonstrates photocatalytic trifluoromethylation and disulfuration in alkenes, suggesting practical applications for pharmaceuticals.

Yu et al. (2025) studied this question.

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This method demonstrates photocatalytic trifluoromethylation and disulfuration in alkenes, suggesting practical applications for pharmaceuticals.