September 10, 2025Organic Letters

Photoredox Catalytic Approach for Difluoroallylation of Electron-Deficient sp³ C–H Bonds

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The photoredox protocol enables selective difluoroallylation of electron-deficient sp3 C–H bonds with α-trifluoromethyl alkenes.
Use of 2,2,6,6-tetramethylpiperidine as an additive eliminates hazardous reagents typically required in C–H bond functionalization.
The method supports mild conditions and good functional group compatibility, promoting scalability and late-stage modifications.
Preliminary mechanistic studies indicate the involvement of α-functionalized alkyl radical intermediates, revealing insight into the reaction pathway.

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This photoredox approach enhances difluoroallylation outcomes in electron-deficient sp3 C–H bonds, suggesting practical applications.

Fan et al. (2025) studied this question.

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