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October 9, 2025Circulation Research

Abstract Wed091: Biomechanical and Transcriptomic Remodeling of the Heart in Heart Failure with Preserved Ejection Fraction

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Authors

TGTatiana GromovaNGNatalie GehredHMHafsa Mamsa

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Overview

Rodent model reveals hypertension and obesity as contributors to heart failure progression, indicating novel ECM remodeling.

Key Points

  • Hypertension and obesity both contributed to elevated systolic blood pressure and impaired exercise capacity in mice.
  • RNA sequencing revealed key gene programs involved in heart failure with preserved ejection fraction, highlighting shared and unique remodeling pathways.
  • The combination of high fat diet and L-NAME significantly affected cardiac function, particularly in diastolic dysfunction measurements.
  • Findings suggest extracellular matrix remodeling and transcriptional changes play critical roles in developing heart failure with preserved ejection fraction.

Cite This Study

Gromova et al. (2025) studied this question.

synapsesocial.com/papers/68e80eb363e2e2f707877d60https://doi.org/10.1161/res.137.suppl_1.wed091
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: etiology and sex-dependent differences2025 · 7 citations
  2. 2Abstract Wed082: Integrated Systems Biology Identifies Disruptions In Mitochondrial Function And Metabolism As Key Contributors To HFpEF2025
  3. 3Abstract Wed089: Deciphering transcriptome and cell-cell communication signature in heart failure with preserved ejection fraction at single cell resolution2025
  4. 4Abstract Fri112: Mitochondrial Maladaptation at the Crossroads of Heart Failure: A Tale of Two Phenotypes2025
  5. 5Abstract Wed077: The role of senescence in HFpEF induced by cardiometabolic syndrome2025