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October 10, 2025Circulation Research

Abstract Wed089: Deciphering transcriptome and cell-cell communication signature in heart failure with preserved ejection fraction at single cell resolution

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Authors

JHJijun HuangCZChaoqun ZhuDPDiana Pham

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Overview

Analysis reveals altered transcriptome and cell-cell communication in heart failure, suggesting insulin's role.

Key Points

  • Altered transcriptional profiles indicate cellular communication changes in heart failure with preserved ejection fraction.
  • Diastolic dysfunction was exacerbated in insulin receptor knockout models fed a high fat diet.
  • Single nuclei RNA sequencing elucidated significant transcriptional changes across cell types in heart failure.
  • Insulin signaling appears integral to organ-wide communication mechanisms in the progression of heart failure.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68e861a57ef2f04ca37e47cbhttps://doi.org/10.1161/res.137.suppl_1.wed089
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