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October 9, 2025Circulation Research

Abstract Fri112: Mitochondrial Maladaptation at the Crossroads of Heart Failure: A Tale of Two Phenotypes

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Authors

KKKarthickeyan Chella KrishnanJFJames FrazierXHXingyu He

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Overview

Analysis reveals how mitochondrial function impacts heart failure with preserved and reduced ejection fraction.

Key Points

  • HFrEF shows impaired respiratory capacity, highlighting a critical metabolic disruption in heart function.
  • Findings reveal that reduced LRPPRC protein levels correlate with severe heart failure in mice with the GG genetic locus.
  • The study identifies sex-specific protective roles of NDUFV2 in females, improving outcomes in HFpEF.
  • Restoring mitochondrial balance could offer innovative therapeutic strategies targeting both HFrEF and HFpEF.

Cite This Study

Krishnan et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb08https://doi.org/10.1161/res.137.suppl_1.fri112
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