Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
October 9, 2025Circulation Research

Abstract Wed077: The role of senescence in HFpEF induced by cardiometabolic syndrome

View Full Paper
Ask AI
Bookmark
Share

Authors

DDDao‐Fu DaiKWKaihao Wang

Discussion

Loading...

Member takes

Overview

This study demonstrates that senescence is linked to HFpEF in mice with cardiometabolic syndrome, indicating potential therapeutic insights.

Key Points

  • HFpEF phenotypes improved significantly after genetic senolytic therapy in mice exposed to multiple comorbidities.
  • The 4-Hit mouse model showed approximately 50% increase in left ventricular mass despite stable ejection fraction.
  • Senolytic treatment reduced macrophage infiltration in the hearts of mice with cardiometabolic stress.
  • Analysis revealed significant pathways affected by senescence, including mitochondrial dysfunction and inflammation.

Cite This Study

Dai et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb9fhttps://doi.org/10.1161/res.137.suppl_1.wed077
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pharmacological clearance of senescent cells reduces inflammation, endothelial damage and cardiac fibrosis in HFpEF2025 · 10 citations
  2. 2Abstract Wed091: Biomechanical and Transcriptomic Remodeling of the Heart in Heart Failure with Preserved Ejection Fraction2025
  3. 3Abstract Wed082: Integrated Systems Biology Identifies Disruptions In Mitochondrial Function And Metabolism As Key Contributors To HFpEF2025
  4. 4NAD⁺ Replenishment Mitigates Cardiomyocyte Senescence and Corrects Heart Failure with Preserved Ejection Fraction in Aged Mice.2025 · 2 citations
  5. 5Abstract Wed080: Cardiac-specific mTORC1 Suppression Protects Against the Development of Heart Failure with Preserved Ejection Fraction2025