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October 9, 2025Circulation Research

Abstract Wed082: Integrated Systems Biology Identifies Disruptions In Mitochondrial Function And Metabolism As Key Contributors To HFpEF

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Authors

AGAndrew GibbKLKyle B. LaPennaRGRyan B. Gaspar

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Overview

Observational analysis uncovers metabolic shifts and mitochondrial dysfunction in HFpEF, indicating key pathways for intervention.

Key Points

  • Transcriptional analysis revealed significant changes in 5,691 genes in ZSF1-obese rats, linking mitochondrial dysfunction to HFpEF.
  • Metabolic profiling indicated a shift from β-oxidation to glycolysis in hypertensive rats, suggesting altered energy metabolism.
  • Integrated omics highlighted reduced respiratory rates by ~25% in ZSF1-obese rats, indicating compromised mitochondrial function.
  • Analysis of cardiomyocyte structure showed cristae disorganization and significant lipid droplet accumulation in HFpEF hearts.

Cite This Study

Gibb et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fb0dhttps://doi.org/10.1161/res.137.suppl_1.wed082
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract Wed091: Biomechanical and Transcriptomic Remodeling of the Heart in Heart Failure with Preserved Ejection Fraction2025
  2. 2Abstract Fri112: Mitochondrial Maladaptation at the Crossroads of Heart Failure: A Tale of Two Phenotypes2025
  3. 3Abstract Wed088: Distinct Multi-Omic Signatures Differentiate Type I Diabetes-Associated HFpEF from Obesity-Related HFpEF2025
  4. 4Pathophysiology of HFpEF: Insights from a Metabolic–Mitochondrial Perspective2025 · 12 citations
  5. 5Abstract Wed077: The role of senescence in HFpEF induced by cardiometabolic syndrome2025