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September 5, 2025Open Access

Glycated CD59 as a Novel Biomarker of Diabetic Nephropathy: Links to Microalbuminuria, Tubular Injury, and Complement Activation

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Authors

BCBhagatsingh ChintaSPS. K. PadmaRKRamesh Kandimalla

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Overview

Study finds glycated cd59 correlates with microalbuminuria and tubular injury in type 2 diabetes, suggesting new biomarker potential.

Key Points

  • Glycated cd59 is significantly elevated in patients with microalbuminuria, indicating its potential as a biomarker for diabetic nephropathy.
  • Correlation analysis shows a strong association between glycated cd59 and other renal injury markers like urinary NGAL and hs-crp.
  • Independent predictors of microalbuminuria include glycated cd59, urinary NGAL/KIM-1, and complement activation marker sMAC.
  • Use of ACEi/ARB and SGLT2i therapies correlates with lower levels of biomarkers and improved renal function.

Cite This Study

Chinta et al. (2025) studied this question.

synapsesocial.com/papers/68c23966b210217d6477c150https://doi.org/10.20944/preprints202508.2144.v1
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