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October 9, 2025Circulation Research

Abstract Wed088: Distinct Multi-Omic Signatures Differentiate Type I Diabetes-Associated HFpEF from Obesity-Related HFpEF

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Authors

LWLin WeiCapital Medical UniversityPHPatrick C. HsiehUniversity of Southern California

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Implication

This study reveals distinct mechanisms of HFpEF in type 1 diabetes and obesity, highlighting therapeutic targets for intervention.

Key Points

  • Distinct cardiac remodeling mechanisms are observed in HFpEF patients with type 1 diabetes compared to obesity.
  • Single-cell profiling indicated unique chromatin changes and gene expression patterns in diabetic versus obesity-related HFpEF.
  • Metabolomic and gut microbiome analyses uncover unique metabolic disruptions linked to both HFpEF models.
  • This research emphasizes different inflammatory and metabolic pathways contributing to HFpEF progression in type 1 diabetes.

Cite This Study

Wei et al. (2025) studied this question.

synapsesocial.com/papers/68e77f09d1c187e1c108fbbahttps://doi.org/10.1161/res.137.suppl_1.wed088
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Excitation-contraction coupling, cardiomyocyte electrophysiology, and transcriptome profiles in two HFpEF murine models: etiology and sex-dependent differences2025 · 7 citations
  2. 2Abstract Wed082: Integrated Systems Biology Identifies Disruptions In Mitochondrial Function And Metabolism As Key Contributors To HFpEF2025
  3. 3Abstract Wed091: Biomechanical and Transcriptomic Remodeling of the Heart in Heart Failure with Preserved Ejection Fraction2025
  4. 4Abstract Wed092: Embracing the complex pathophysiology of heart failure with preserved ejection fraction by developing rodent models to feature different patients’ phenogroups.2025
  5. 5HFpEF as the Predominant and Underrecognized Heart Failure Phenotype in Type 2 Diabetes: Evidence from the DIABET-IC Study2025