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October 8, 2025

Elp3 activates the JNK/MAPK pathway through histone acetylation to promote gastric cancer proliferation, migration, and invasion.

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Authors

JDJi DiHSHao ShangXSXiali Shi

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Overview

Observational analysis reveals Elp3's role in gastric cancer progression, suggesting JNK/MAPK pathway involvement.

Key Points

  • Elp3 overexpression increases gastric cancer cell proliferation, migration, and invasion, indicating its significant role.
  • Histone acetylation inhibition effectively reduces the effects of Elp3 overexpression on gastric cancer behavior.
  • Elp3 interacts with JNK1, highlighting a crucial relationship in activating the JNK/MAPK signaling pathway.
  • Inhibition of the JNK/MAPK pathway diminishes the promotion of gastric cancer by Elp3, suggesting therapeutic potential.

Cite This Study

Di et al. (2025) studied this question.

synapsesocial.com/papers/68e6d7971ffa7aa7d63d1673https://doi.org/10.14670/hh-25-001
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