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September 18, 2025NeoplasmaOpen Access

ELK1 modulates SF3B3 transcriptional activity to stimulate proliferation and inhibit apoptosis in gastric cancer through the activation of the MAPK pathway

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Authors

YZYaqing ZhangLGLei GaoLLLixin Liu

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Overview

This analysis reveals how SF3B3 regulates proliferation and apoptosis in gastric cancer, highlighting the MAPK pathway's role.

Key Points

  • SF3B3 promotes gastric cancer cell proliferation and inhibits apoptosis by activating the MAPK pathway, leading to tumor growth.
  • Upregulation of SF3B3 in gastric cancer tissues is associated with poor prognosis and higher immune infiltration.
  • In vitro and in vivo experiments demonstrated SF3B3 knockdown reduces proliferation, migration, and invasion of gastric cancer cells.
  • ELK1 positively regulates SF3B3 expression, suggesting a significant correlation in the ELK1-SF3B3-MAPK axis driving gastric cancer progression.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68d434e3713b0b5dfea744b2https://doi.org/10.4149/neo_2025_250219n83
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elp3 activates the JNK/MAPK pathway through histone acetylation to promote gastric cancer proliferation, migration, and invasion.2025
  2. 2Exploration of the association between <i>SF3B4</i> and <i>HMGB1</i> expression and the clinicopathological features and prognosis of gastric cancer2025
  3. 3Novel therapeutics for SF3B1 mutant cancers which exploit the missplicing of DCAF162025 · 1 citations
  4. 4ZC3H13 mediates N6-methyladenosine modification of SNTB1 to promote epithelial-mesenchymal transition in gastric cancer2025
  5. 5Abstract Thu111: The splicing factor SF3B1 in regulating endothelial gene expression and angiogenesis2025