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August 26, 2025Cancer MedicineOpen Access

The GNL3L‐MDM2 Interaction Drives Esophageal Squamous Cell Carcinoma Progression

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Authors

AYAijie YangHSHaiyun SongYCYufeng Cheng

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Overview

Observational analysis shows GNL3L enhances ESCC malignancy, indicating its role in MDM2 and p53 regulation.

Key Points

  • GNL3L was found to be upregulated in ESCC tissues, correlating with increased malignancy and growth.
  • Cell proliferation and migration decreased when GNL3L was knocked down, while apoptosis increased significantly.
  • The interaction between GNL3L and MDM2 was confirmed, with impacts on p53 and p21 levels noted with gene knockdowns.
  • In vivo studies demonstrated that reduced GNL3L expression led to smaller tumor sizes, highlighting its role in cancer progression.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68af7e047567bf4f94ff57cchttps://doi.org/10.1002/cam4.71146
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