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September 10, 2025Molecular Pharmacology

Heterogeneous Nuclear Ribonucleoprotein A/B Drives Gastric Cancer and EMT via Akt-GSK3β-Wnt Pathway

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Authors

LHLuo HuiruATA TraoréJHJunyi Hu

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Overview

Exploratory analysis shows HNRNPAB enhances cancer cell proliferation and migration, indicating potential as a therapeutic target.

Key Points

  • Overexpression of HNRNPAB in gastric cancer cells significantly enhances cell proliferation, migration, and invasion.
  • Increased levels of HNRNPAB were observed in metastatic gastric cancer cells and tissues compared to normal tissues.
  • Modulation of the Akt-GSK3β-Wnt pathway by HNRNPAB promotes epithelial-mesenchymal transition, correlating with higher metastatic potential.
  • Findings suggest HNRNPAB could serve as a biomarker and therapeutic target for gastric cancer treatment.

Cite This Study

Huiru et al. (2025) studied this question.

synapsesocial.com/papers/68c24236b210217d647a2a2ehttps://doi.org/10.1016/j.molpha.2025.100066
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