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October 2, 2025MedicineOpen Access

Risk factors for mortality in febrile neutropenic patients treated with colistin

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Authors

CYCumali YALÇINVÖVildan ÖzkocamanTETuba Ersal

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Overview

Analysis reveals mortality risks in febrile neutropenic patients treated with colistin, indicating timely intervention is crucial.

Key Points

  • Delaying colistin treatment after 5 days significantly increases the risk of mortality due to febrile neutropenia and sepsis.
  • Patients with sepsis or septic shock showed a hazard ratio of 5.02, emphasizing the impact of acute conditions on outcomes.
  • Isolated gram-negative bacteria like K. pneumoniae and A. baumannii were linked to higher mortality rates among culture-positive patients.
  • The presence of invasive pulmonary aspergillosis also increased mortality risk, underscoring the need for rapid treatment initiation.

Cite This Study

YALÇIN et al. (2025) studied this question.

synapsesocial.com/papers/68de79685b556a9128e1a983https://doi.org/10.1097/md.0000000000044841
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of different colistin sulfate regimens for carbapenem-resistant gram-negative bacteria pneumonia in neurocritical care patients: a retrospective cohort study2025
  2. 2Safety Monitoring of Colistin Therapy in Critically Ill Neonates With Late‐Onset Sepsis: A Retrospective Observational Study2025
  3. 3Efficacy and Safety of Three Colistin Regimens in the Treatment of Nosocomial Pneumonia Caused by Carbapenem-Resistant Organisms: A Single Centre, Open Label, Prospective Cohort Study2025
  4. 4Acute kidney injury of intravenous colistin sulfate compared with colistimethate sodium: a real-world, retrospective cohort study2025
  5. 5Evaluation of Colistin Susceptibility among Multidrug-Resistant Gram- Negative Pathogens isolated from Blood Culture: Evidence from a Tertiary Care Setting in Delhi, India2025