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September 23, 2025Antimicrobial Agents and ChemotherapyOpen Access

Comparison of different colistin sulfate regimens for carbapenem-resistant gram-negative bacteria pneumonia in neurocritical care patients: a retrospective cohort study

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Authors

QZQian ZengHHHua-Wei HuangJLJiaqi Lu

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Overview

Retrospective cohort study compares clinical outcomes of colistin sulfate regimens in CR-GNB pneumonia patients, suggesting combinations may improve efficacy.

Key Points

  • Nebulized colistin sulfate with intravenous administration showed lower clinical failure rates compared to intravenous alone.
  • Clinical failure rates on day 14 were lower in the nebulized group at 14.2% compared to 32.1% in the intravenous group.
  • No significant differences in mortality risk or nephrotoxicity were observed among the different colistin sulfate regimens.
  • Multivariable analysis identified intravenous colistin sulfate as a factor linked to higher clinical failure on day 14.

Cite This Study

Zeng et al. (2025) studied this question.

synapsesocial.com/papers/68d43d68713b0b5dfea7cf1chttps://doi.org/10.1128/aac.00644-25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative outcomes of polymyxins in neurocritical care patients with carbapenem-resistant Gram-negative bacterial pneumonia: a retrospective cohort study2025
  2. 2Efficacy and Safety of Three Colistin Regimens in the Treatment of Nosocomial Pneumonia Caused by Carbapenem-Resistant Organisms: A Single Centre, Open Label, Prospective Cohort Study2025
  3. 3A Tentative Clinical Study: Colistin Combined with Ceftazidime/Avibactam in the Treatment of Carbapenem-Resistant Gram-Negative Bacilli Infection2025 · 2 citations
  4. 4Safety Monitoring of Colistin Therapy in Critically Ill Neonates With Late‐Onset Sepsis: A Retrospective Observational Study2025
  5. 5Risk factors for mortality in febrile neutropenic patients treated with colistin2025