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July 23, 2025

Efficacy and Safety of Three Colistin Regimens in the Treatment of Nosocomial Pneumonia Caused by Carbapenem-Resistant Organisms: A Single Centre, Open Label, Prospective Cohort Study

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Authors

WQWei QinXCXinxing ChenFXFeng Xu

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Overview

Prospective cohort study evaluates clinical efficacy of colistin regimens in nosocomial pneumonia, indicating inhaled delivery's effectiveness.

Key Points

  • Clinical efficacy rates were 70.0% for inhalation, 64.7% for combined administration, and 64.3% for intravenous, indicating comparable outcomes.
  • Inhalation showed superior microbiological response compared to intravenous, suggesting an effective alternative for treatment.
  • Ninety-eight patients with nosocomial pneumonia caused by carbapenem-resistant organisms were analyzed in a single-center study.
  • The study highlights the importance of administration routes and factors like APACHE II scores in treatment outcomes.

Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/689a0621e6551bb0af8cdbc9https://doi.org/10.21203/rs.3.rs-6911404/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of different colistin sulfate regimens for carbapenem-resistant gram-negative bacteria pneumonia in neurocritical care patients: a retrospective cohort study2025
  2. 2Comparative outcomes of polymyxins in neurocritical care patients with carbapenem-resistant Gram-negative bacterial pneumonia: a retrospective cohort study2025
  3. 3A Tentative Clinical Study: Colistin Combined with Ceftazidime/Avibactam in the Treatment of Carbapenem-Resistant Gram-Negative Bacilli Infection2025 · 2 citations
  4. 4Evaluation of Colistin Susceptibility among Multidrug-Resistant Gram- Negative Pathogens isolated from Blood Culture: Evidence from a Tertiary Care Setting in Delhi, India2025
  5. 5In Vitro Synergistic Activity of Fosfomycin-Colistin Combination Against Carbapenem-Resistant Pseudomonas Aeruginosa from Ventilator-Associated Pneumonia Patients2025