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September 10, 2025BMC Infectious DiseasesOpen Access

Acute kidney injury of intravenous colistin sulfate compared with colistimethate sodium: a real-world, retrospective cohort study

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Authors

PYPing YangWSWei ShuaiJYJu Yang

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Overview

Retrospective cohort study reveals higher AKI rates with colistimethate sodium, indicating safety concerns.

Key Points

  • Patients receiving colistin methanesulfonate experienced a significantly higher AKI incidence compared to those on colistin sulfate.
  • In unmatched cohorts, the AKI incidence was 29.70% for CMS versus 7.37% for CS, showing a significant difference in nephrotoxicity.
  • Cox proportional hazard analysis identified CMS therapy and lower baseline eGFR as independent risk factors for AKI.
  • The study suggests an urgent need for prospective multicenter research to validate the findings on nephrotoxicity.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68c24236b210217d647a2ce0https://doi.org/10.1186/s12879-025-11401-8
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