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September 10, 2025Journal of Medical Bacteriology

Evaluation of Colistin Susceptibility among Multidrug-Resistant Gram- Negative Pathogens isolated from Blood Culture: Evidence from a Tertiary Care Setting in Delhi, India

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Authors

SNSwati NirmalKNKirti NirmalHJHaarish Jayaraj

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Overview

Cross-sectional analysis shows 100% antibiotic resistance in MDR gram-negative pathogens, indicating urgent need for colistin stewardship.

Key Points

  • The study found that 100% of Enterobacter and Klebsiella species were resistant to most antibiotics.
  • A total of 74 (92.5%) of tested isolates were confirmed as carbapenem-resistant using the mCIM method.
  • All 74 isolates showed intermediate colistin susceptibility, with 43.2% exhibiting an MIC of 0.031 μg/mL.
  • The results highlight the critical need for enhanced monitoring of colistin resistance, particularly in NICUs.

Cite This Study

Nirmal et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478b526https://doi.org/10.18502/jmb.v13i3.19504
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Also Consider

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  1. 1A-254 Molecular characterization of carbapenem and colistin resistance in isolates causing UTI at an outpatient setting of a tertiary care hospital2025
  2. 2P28 Assessment of colistin susceptibility in carbapenem-resistant <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i> : a comparison of diagnostics MIC-COL and VITEK® 2 AST-XN21 with broth microdilution2025
  3. 3Molecular characterization of colistin resistance in carbapenem-resistant <i>Klebsiella pneumoniae</i> from a tertiary hospital in China2025
  4. 4The Evaluation of Two Colistin Minimum Inhibitory Concentration (MIC) Methods: A Comparative Study of MicroScan Walkaway 96 Plus ID/AST and Colistin Broth Disc Elution Test at a Tertiary Care Hospital in Punjab2025
  5. 5Emergence, Molecular Characteristics and Resistance Mechanisms of Colistin-Resistant Enterobacterales in Xuzhou, China2025