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October 2, 2025Open Access

Mapping the miRNA Landscape of Gallbladder Cancer: Genome-Wide Insights and Functional Implications

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Authors

SSShachi Jenny SharmaGSGarima SinghSMS. P. Mathur

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Overview

Genome-wide profiling of miRNAs identifies 388 differentially expressed miRNAs in gallbladder cancer, suggesting therapeutic targets in its pathogenesis.

Key Points

  • Significantly differentially expressed miRNAs target key processes like cell adhesion and apoptosis, revealing insights into gallbladder cancer.
  • A total of 971 known and 27 novel microRNAs were profiled, highlighting the complexity of miRNA contributions to gallbladder cancer progression.
  • The suppressed miR-17~92 cluster was identified as a regulator of S-phase licensing factor Cdt2, impacting cell proliferation and invasion uniquely in cancer cells.
  • Profiling presents opportunities for miRNA-based diagnostics and therapies, specifically targeting the oncogenic potential of specific miRNAs.

Cite This Study

Sharma et al. (2025) studied this question.

synapsesocial.com/papers/68de6f3683cbc991d0a225a3https://doi.org/10.1101/2025.09.29.679165
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcriptomic landscape of Gallbladder cancer reveals altered pathways related to cell cycle and Aurora kinase2025
  2. 2Identification and verification of the key genes involved in gallbladder cancer2025
  3. 3Dysregulated <scp>RNA m6A</scp> Methylation Contributes to the Metastasis of Gallbladder Cancer Through <scp>miR</scp>‐146a‐5p2025 · 2 citations
  4. 4Dysregulated MicroRNAs in Urinary Non-Muscle-Invasive Bladder Cancer: From Molecular Characterization to Clinical Applicability2025
  5. 5Association of miRNA-17-92 Cluster with Muscle Invasion in Bladder Cancer2025