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August 12, 2025Journal of Cellular and Molecular MedicineOpen Access

Dysregulated RNA m6A Methylation Contributes to the Metastasis of Gallbladder Cancer Through miR‐146a‐5p

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Authors

YLYu-Hui LiuRHRuizhi HeWWWenjia Wang

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Overview

Observational analysis shows m6A modification impacts metastasis in gallbladder cancer, suggesting new treatment strategies.

Key Points

  • m6A modification influences the metastatic behavior of gallbladder cancer cells, revealing a critical pathway.
  • Key findings indicate significant downregulation of m6A levels, METTL3, and METTL14 in cancerous tissues compared to normal ones.
  • This observational study utilized a liver metastasis model and in vitro experiments to explore the molecular mechanisms involved.
  • The results highlight the potential for targeting m6A and its regulatory factors in gallbladder cancer treatment.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c23595b210217d64771292https://doi.org/10.1111/jcmm.70764
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unraveling the dual role of METTL3-mediated m <sup>6</sup> A RNA modification in bladder cancer: mechanisms, therapeutic vulnerabilities, and clinical implications2025
  2. 2Mapping the miRNA Landscape of Gallbladder Cancer: Genome-Wide Insights and Functional Implications2025
  3. 3METTL3-mediated m6A modification of DNMT1 enhances ovarian cancer progression2025
  4. 4Loss of <scp><i>METTL3</i> m6A</scp> methyltransferase results in short‐term progression and poor treatment outcome of bladder cancer patients2025
  5. 5N7-methylguanosine (m7G) modification in breast cancer: clinical significances and molecular mechanisms2025 · 6 citations