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August 25, 2025CancersOpen Access

Dysregulated MicroRNAs in Urinary Non-Muscle-Invasive Bladder Cancer: From Molecular Characterization to Clinical Applicability

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Authors

NBNouha Setti BoubakerAGAymone GurtnerSBSami Boussetta

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Overview

Observational analysis shows elevated microRNAs predict outcomes in non-muscle-invasive bladder cancer, suggesting improved risk stratification.

Key Points

  • High expression of let-7g and miR-9 predicts better overall survival in high-grade non-muscle-invasive bladder cancer, emphasizing their prognostic importance.
  • MiR-205 and miR-27a accurately forecast intermediate-risk non-muscle-invasive bladder cancer progression and recurrence, establishing critical biomarkers.
  • Analysis included 90 patients with primary bladder cancer, utilizing Kaplan–Meier and Cox regression methods to determine survival and risk associations.
  • The findings highlight the need for larger studies to validate these microRNAs as biomarkers and their potential for integration into liquid biopsy tests.

Cite This Study

Boubaker et al. (2025) studied this question.

synapsesocial.com/papers/68af7f407567bf4f94ff5f14https://doi.org/10.3390/cancers17172768
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Non-Invasive Diagnostic Evaluation of Urinary Exosomal Let-7c Cluster Expression in Bladder Cancer Using Machine Learning Approaches2025
  2. 2Urinary microRNAs as Prognostic Biomarkers for Predicting the Efficacy of Immune Checkpoint Inhibitors in Patients with Urothelial Carcinoma2025
  3. 3Urinary microRNA Profiles Discriminate Bladder Cancer from Healthy Individuals: A Pilot Study Using qPCR Across Urine Fractions.2025
  4. 4The miRNA–immune axis in bladder cancer: systematic evidence for a new era of immunotherapy precision2025
  5. 5miR-25-3p Modulates Tumor Aggressiveness and Ferroptosis Escape in T24 Bladder Cancer Cells In Vitro2025