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September 12, 2025Open Access

Transcriptomic landscape of Gallbladder cancer reveals altered pathways related to cell cycle and Aurora kinase

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Authors

SSSajib SarkarANArnab NayekRMRashmi Minocha

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Overview

Functional analysis shows dysregulation in cell cycle and aurora kinase pathways in gallbladder cancer.

Key Points

  • A total of 621 differentially expressed genes were identified in gallbladder cancer samples, highlighting significant molecular changes.
  • Gene set enrichment analysis indicated activation of cell cycle-related pathways, particularly E2F targets and the G2/M checkpoint.
  • WGCNA revealed a tumor grade-correlated module enriched in cell cycle genes, suggesting important roles in disease progression.
  • TPX2, a hub gene related to aurora kinase, was validated as a key driver of proliferation and invasion in gallbladder cancer cells.

Cite This Study

Sarkar et al. (2025) studied this question.

synapsesocial.com/papers/68d41ee7713b0b5dfea6852fhttps://doi.org/10.1101/2025.09.04.674273
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