Surgical removal of visceral adipose tissue improves metabolism and cognition in symptomatic APP NL-F males, indicating sex-specific responses to treatment.
Key Points
Symptomatic male APP NL-F mice showed improved cognition and metabolism after visceral fat removal, enhancing overall health.
At 18 months, changes in glucose metabolism and novel object recognition were observed primarily in symptomatic males.
Surgical resection of visceral adipose tissue was performed on male and female mice to assess therapeutic outcomes.
Findings suggest metabolic and cognitive benefits may be gender-dependent, highlighting the need for tailored approaches.