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May 13, 2026Kidney Research and Clinical PracticeOpen Access

Mitochondrial metabolism and dynamics in the development of diabetic kidney disease

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Authors

GMGerry George Mathew

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Overview

Narrative review evaluates mitochondrial dysfunction in diabetic kidney disease and emerging therapies.

Key Points

  • This review aims to synthesize recent insights into mitochondrial metabolism and its role in diabetic kidney disease (DKD) progression.
  • Conducted a narrative review of literature published from 2000 to 2025 across multiple databases.
  • Identified mechanisms of mitochondrial dysfunction and their impact on DKD pathology.
  • Evaluated emerging therapies targeting mitochondrial metabolism.
  • Mitochondrial dysfunction linked to DKD progression through impaired oxidative phosphorylation and increased reactive oxygen species.
  • Key regulators like PTEN-induced putative kinase 1 and dynamin-related protein 1 play significant roles in mitochondrial dynamics.
  • Only SGLT2 inhibitors demonstrated robust support in randomized controlled trials as a therapeutic option.

Cite This Study

Gerry George Mathew (2026) studied this question.

synapsesocial.com/papers/6a0414a279e20c90b444499chttps://doi.org/10.23876/j.krcp.25.413
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  5. 5Advancements in Pharmacotherapy for Diabetic Kidney Disease: A Systematic Review2025 · 7 citations